Kratom or Mitragyna speciosa is a native plant to Southeast Asia regions such as Thailand, Indonesia, Myanmar, and Malaysia. The abusive concern for kratom centers on two organic compounds called alkaloids contained within the leaves: mitragynine (MG) and 7-hydroxymitragynine (7-HMG). Future studies should explicitly examine the effects of the combination in complex patterns of polydrug intake, including kratom, to fully understand the synergistic effects and associated clinical and toxicological implications.
The opioid agonistic effects of other constituents of Mitragyna speciosa have also been studied and among them, 7-hydroxymitragynine, an oxidized form of mitragynine (α-hydroxyl group at the C7 position) has shown the most potent effect. Following successful withdrawal from kratom, drug rehabilitation treatment at an inpatient or outpatient facility can help patients successfully recover from addiction and regain their health.
Some strains like Green Maeng Da and White Borneo are considered to be very stimulating and energizing while other strains like Red Bali or Red Thai are said to be calming and sedating. Dosing for pain relief is moderate to high depending on the severity of pain and the following strains in the red vein variety have been shown to be most effective.
Its alkaloids are not traditional opioids, but they can partially bind with opioid receptors in place of opiate drugs and thus help in easing the effects of addiction (Greene, 2013). Kratom (Mitragyna speciosa) is a tropical evergreen tree in the coffee family.
In some cases, kratom products had been adulterated with opioids or other drugs. Deaths reported by the FDA have involved one person who had no historical or toxicologic evidence of opioid use, except for kratom seeds. Some people take kratom to avoid the symptoms of opioid withdrawal and because kratom may be bought more easily than prescription drugs.